| abstract |
The present invention relates to a macrocyclic azolopyridine derivative of Formula I or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof and a composition thereof, embryonic ectoderm development (EED) ) and to a modulator of EEC and/or PRC2 useful in the treatment of disorders or diseases associated with polycomb inhibitory complex 2 (PRC2). Formula (I) In the above formula (I), X 1 , X 2 , X 3 , A 1 , A 2 , Y, R 1 , R 2 , R 3 , and R 4 are described herein. |