| abstract |
Liposomes encapsulating adenosine are provided. Liposomes can be formed by sphingomyelin or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or sphingomyelin and 1,2-dimyristoyl-sn- It may be formed from a combination of glycero-3-phosphorylglycerol (DMPG) or a combination of sphingomyelin, DMPG and DMPC. Liposomes encapsulating adenosine may induce cartilage regeneration, treat osteoarthritis, relieve joint pain, and/or slow, arrest and/or reverse progressive structural tissue damage associated with osteoarthritis, osteoarthritis, rheumatoid arthritis, It may be used to treat acute gouty arthritis and/or synovitis. The liposomes can release adenosine for up to two weeks. |