| abstract |
The present disclosure provides aromatic (eg, pyridinyl, pyrimidinyl, pyrazinyl or phenyl) diamidine analogs and pharmaceutically acceptable salts useful for treating proliferative diseases. The proliferative disease may include a solid cancer or a hematologic cancer. Disclosed herein are compositions, methods of synthesizing them, and methods of treating various cancers using the analogs. The present disclosure also provides a pharmaceutical formulation comprising at least one compound in association with a pharmaceutically acceptable carrier, diluent or excipient. |