| abstract |
The present invention provides compounds having a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present invention comprise a drug moiety, a targeting moiety and an acyl unit capable of targeting a selected cell population, any spacer unit to provide a distance between the drug moiety and the targeting moiety, a peptide linker that can be cleaved under appropriate conditions, hydrophilicity self-immolative linkers and linkers containing an optional second self-immolative spacer or cyclized self-eliminating linker. |