| abstract |
The present invention relates to a long-acting auxintomodulin in which an oxyntomodulin peptide including an oxyntomodulin derivative, mutant, precursor, or fragment is combined with an immunoglobulin Fc region to increase the duration of physiological activity compared to the native type. The present invention relates to an albumin-free liquid formulation in which a lean derivative conjugate can be stably maintained for a long period of time, and to a method for preparing the formulation. The liquid formulation of the long-acting oxyntomodulin conjugate according to the present invention contains a buffer solution, a sugar alcohol and a nonionic surfactant, and does not contain human serum albumin and potentially harmful factors to the human body, so there is no risk of virus infection, It provides excellent storage stability for a long-acting oxyntomodulin conjugate with a higher molecular weight and an increased duration of physiological activity compared to the native type due to the binding of oxyntomodulin and the immunoglobulin Fc region. |