| abstract |
The present invention relates to an oral composition comprising a combination herbal extract composed of longan meat, gobon and raw paper as an active ingredient, which has a preventive or therapeutic effect on inflammatory diseases. Experiments on the effect of the combination herbal extract according to the present invention on the inhibition of cytokine expression using human skin epithelial cells (HaCaT) (Experimental Example 1), cytotoxicity (cell viability) evaluation in HT-29 cells and THP-1 cells ( Experimental Example 2), anti-inflammatory effect test on THP-1 cells of herbal mixture extract (Experimental Example 3), effect test on inflammatory factors Beclin1 and LC3B-1 expression of herbal mixture extract on immune cells (Experimental Example 4) in vitro experiments such as; Arthritis inhibitory effect test (Experimental Example 5), such as pain threshold measurement, weight bearing measurement, histological analysis (Micro-CT) experiment, histopathological analysis experiment, etc. in an arthritis-induced rat experimental model of herbal mixture extract By confirming that the sample exhibits a strong anti-inflammatory effect and arthritis treatment and improvement effect through animal experiments, it is useful as an oral pharmaceutical composition for the prevention and treatment of inflammatory diseases, health functional food or health supplement. |