| abstract |
The present invention provides, inter alia, oligonucleotides, compositions, and methods for preventing and/or treating various conditions, disorders or diseases. In some embodiments, provided oligonucleotides comprise nucleobase modifications, sugar modifications, internucleotide linkage modifications and/or patterns thereof, and have improved properties, activity and/or selectivity. In some embodiments, the present invention provides oligonucleotides, compositions and methods for HTT-associated conditions, disorders or diseases, such as Huntington's disease. |