| abstract |
Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with cyclodextrin and/or carbonate or bicarbonate. Such compositions can be administered orally to improve the bioavailability or pharmacokinetics of NSAIDs, for example, for the treatment of pain, such as migraine, arthritis and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human suffering from pain, such as migraine. In the case of migraine, this method may be particularly useful when meloxicam and rizatriptan are administered while a human is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan can be administered in a manner that results in a T max of meloxicam of 3 hours or less. |