Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cbf4a72441a9802e2698cb95cf6f3949 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
filingDate |
2020-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94b0fdc9b9a163486b10fc8e4be38d7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6ea5a1cc48dff9fa3c14afa88fff6fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8af48295287905eae9986565511c7300 |
publicationDate |
2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20210117524-A |
titleOfInvention |
Use of KAT2B for the diagnosis of ciliary injury disease |
abstract |
The present invention relates to the use of KAT2B for the diagnosis of ciliary damage disease, and to a formulation for preventing or treating ciliary damage disease comprising KAT2B, wherein the biomarker KAT2B according to the present invention is alpha-tubulin (α-tubulin) in cilia. ) was confirmed to promote cilia formation by inducing acetylation, and the degree of acetylation of α-tubulin decreased in KAT2B knockdown and knockout, and IFT proteins and GLI1 By confirming that the expression level is reduced and a glomerular cyst is formed, KAT2B is proposed as a biomarker for the diagnosis of ciliary damage disease, and KAT2B protein is provided as a prophylactic or therapeutic agent for ciliary damage disease. |
priorityDate |
2020-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |