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filingDate 2020-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e17306855d2b0f5cb01225cb958893
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publicationDate 2021-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20210114971-A
titleOfInvention Liposome composition comprising liposomal prodrug of mitomycin C and preparation method
abstract A liposome composition comprising a lipophilic prodrug of mitomycin C with an improved pharmacokinetic profile is described. Methods for preparing compositions using a solvent system consisting of ethanol and tertiary butanol mixed in appropriate ratios are also described. In an embodiment, the liposome composition is a population of lipid nanoparticles and a pharmaceutically acceptable vehicle, wherein the population of lipid nanoparticles consists of a first fraction of spherical liposomes and a second fraction of rod-shaped lipid nanoparticles, and , wherein the second fraction is less than about 15% of the population of lipid nanoparticles.
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