abstract |
0.1 to 5 wt.% (eg, 0.1 to 2.5 wt.%) of a microgel particle-forming polymer; and 0.5 to 100 mM of a monovalent and/or polyvalent metal ion salt as a crosslinking agent. The microgel particle-forming polymer is dispersed in an aqueous vehicle and the hydrogel composition has a pH in the range of 3 to 8. The viscosity of the gel composition decreases when the gel is exposed to shear. Also disclosed are methods of making such compositions and medical uses of such compositions. |