| abstract |
The present invention relates to a method of identifying a human subject suffering from an inflammatory disease capable of responding to therapy, particularly a TREM-1 inhibitor. In particular, the present invention relates to an in vitro method for identifying a human subject suffering from an inflammatory disease, preferably an acute inflammatory disease, eg SIRS, sepsis or septic shock capable of responding to therapy, in particular a TREM-1 inhibitor. wherein the method comprises: a) determining the level of a soluble triggering receptor (sTREM-1) expressed on bone marrow cells-1 in a biological sample of said human subject; b) comparing the level of sTREM-1 measured in step a) with a pre-measured sTREM-1 value; c) an inflammatory disease, preferably an acute inflammatory disease, such as SIRS, sepsis or septic shock having a level of sTREM-1 measured in step a) higher than the pre-measured sTREM-1 value of step b) identifying the afflicted human subject as capable of responding to therapy, particularly a TREM-1 inhibitor. |