http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210100848-A

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filingDate 2020-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80c661a5846a37c8eab4aaa1425cc5c7
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publicationDate 2021-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20210100848-A
titleOfInvention Method for manufacturing nanoparticles having hydrophilic ligands and antibodies conjugated to each surface of them, nanoparticles manufactured using same method, complex containing same nanoparticles, and diagnostic kit containing same nanoparticles
abstract The present invention relates to a method for producing nanoparticles in which a hydrophilic ligand and an antibody are conjugated to a surface, comprising the steps of preparing nanoparticles having a hydrophilic ligand bound to the surface, diluting the nanoparticles in a buffer to form a nanoparticle mixed buffer Step, mixing the antibody with the nanoparticle mixing buffer and stirring to form a nanoparticle-antibody conjugate mixed buffer, and adding a blocking solution to the nanoparticle-antibody conjugate mixed buffer and stirring to mix the blocked nanoparticles-antibody conjugate By including the step of forming a buffer, direct conjugation of the antibody is possible without the need for a separate chemical linker, thereby improving the efficiency and reproducibility of the production process.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022177041-A1
priorityDate 2020-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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