| abstract |
Reduced viscosity selected from the group consisting of hindered amines, aromatic and anionic aromatics, functionalized amino acids, oligopeptides, short chain organic acids, low molecular weight aliphatic polyacids, diones and sulfones, zwitterionic excipients, and clustering agents with hydrogen bonding elements. Disclosed herein is a method for improving a parameter of a protein-related process comprising providing an excipient compound and adding a reducing viscosity amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution comprises a protein of interest; and a carrier solution comprising a liquid medium in which the protein of interest is dissolved and a viscosity reducing excipient, wherein the viscosity of the carrier solution has a viscosity lower than that of the control solution substantially similar to the carrier solution except for the presence of the viscosity reducing excipient. |