| abstract |
Provided are polypeptide derivatives, modified derivatives thereof or salts thereof, and uses of said polypeptide derivatives, modified derivatives thereof or salts thereof, wherein said polypeptide derivatives, modified derivatives thereof or salts thereof include a polypeptide having the sequence In general formula Ⅰ: HX 2 QGTFTSDX 10 SX 12 YLX 15 X 16 X 17 X 18 AX 20 EFX 23 X 24 WLX 27 X 28 X 29 X 30 X 31 , in the general formula Ⅰ, X 2 , X 10 , X The definitions of 12 , X 15 , X 16 , X 17 , X 18 , X 20 , X 23 , X 24 , X 27 , X 28 , X 29 , X 30 and X 31 are as defined in the claims and specification. The polypeptide derivative has a dual action effect on the GC/GLP-1 receptor, has a synergistic effect on energy metabolism, and can reduce weight and improve body fat level while effectively lowering blood sugar, and the drug effect is a single GLP-1 receptor agonist superior to |