| abstract |
The present invention relates generally to controlled release of tetracycline antibiotics. More specifically, the present invention relates to a complex comprising a tetracycline compound (TC) or a pharmaceutically acceptable salt, hydrate or solvate thereof and a divalent metal carboxylate; Pharmaceutical preparations comprising complexes, complexes and methods for the preparation of pharmaceutical preparations, and for use in methods of treatment of the human or animal body, in particular for the treatment and/or prophylaxis of bacterial infections; and/or antibiotic activity is maintained for a long time; and/or to a complex or pharmaceutical agent for treating and/or preventing acute, chronic or recurrent periodontal disease. |