| abstract |
Disclosed herein are MDSC-targeted extracellular vesicles (EVs) loaded with therapeutic cargoes, as well as compositions, systems and methods for making same. Also disclosed herein are MDSC-targeting ligands, such as fusion proteins containing an MDSC-targeting moiety. Also disclosed are EVs containing the disclosed fusion proteins. In some embodiments, the EV is also loaded with a therapeutic cargo. Also disclosed are EV producing cells engineered to produce the disclosed EVs. Also disclosed is a method of making a disclosed EV comprising culturing the disclosed EV producing cell under conditions suitable for producing the EV. |