| abstract |
The present invention relates to methods for simultaneous detection and enrichment of antigen-specific T cells and peptides specifically recognized by their T cell receptor (TCR). The invention also relates to T cells for in vivo and/or in vitro intervention, including vaccination, induction of immunological tolerance, blockade of TCR and MHC-mediated toxin delivery, for immunogenicity tests and other in vitro T-cell reactivity tests. - Allows the identification of specific antigens. The present invention also relates to the chimeric molecule used in the method. |