| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b35defdaf2eb371391cf1b2e32fb71a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2200-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-086 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M41-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502761 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01L3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0793
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-079
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2019-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caa316360f06dc80decda50403fc57a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c7efc5ecda0b0177fe0b95213052583 |
| publicationDate |
2021-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20210070537-A |
| titleOfInvention |
Neuron on a chip for efficacy and toxicity tests to nerves and uses thereof |
| abstract |
The present invention relates to a biomimetic nerve chip for evaluating the efficacy and toxicity of a drug comprising an astrocyte supply unit and a nerve cell supply unit for mimicking neural tissue, and a culture medium supply unit for supplying a culture medium to the astrocyte supply unit and the nerve cell supply unit, the A method for evaluating the efficacy of a drug on nerve cells through astrocytes using a biomimetic nerve chip, and a method for evaluating the toxicity of a drug on a nerve cell through astrocytes using the biomimetic nerve chip. By using the biomimetic nerve chip for evaluating the efficacy and toxicity of the drug provided in the present invention, it is possible to overcome the inaccuracy due to the difference between different species of animal experiments in the study of nervous tissue, and by using astrocytes and nerve cells in combination It can be used as a platform to evaluate the efficacy and toxicity of drugs more accurately under conditions similar to in vivo conditions, and can be applied to microenvironment research in neural tissue and other organ-on-a-chip research. Therefore, it may be utilized in the development of a human-on-a-chip that can effectively analyze drug efficacy and toxicity. |
| priorityDate |
2019-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |