| abstract |
The present invention relates to a compound of structure I or a pharmaceutically acceptable salt, solvate, active metabolite, polymorphic substance, ester, optical isomer or prodrug thereof, a drug composition comprising the compound of structure I and BTK thereof A Bruton's tyrosine kinase inhibitor with high selectivity for the (C481S) mutant is used for the manufacture of a drug for preventing or treating heterologous immune disease, autoimmune disease or cancer. formula I |