| abstract |
<Task> An object of the present invention is to provide an aqueous suspension containing a macrolide-based antimicrobial agent as an active ingredient. Specifically, an object of the present invention is to provide a pharmaceutical composition containing as an active ingredient a macrolide antibiotic that can be put into practice. <Solution> The present invention is an aqueous suspension formulation comprising nanoparticles of macrolide antibiotics and a dispersion stabilizer, an aqueous suspension formulation having an average particle diameter of the nanoparticles of 500 nm or less and a D90 particle diameter of 1500 nm or less, and a parenteral containing the aqueous suspension To provide a pharmaceutical composition for oral administration, an injection, an eye drop or an ear drop, more specifically an eye drop for the treatment or prevention of an inflammatory disease of the eye, or an ear drop for the treatment or prevention of an inflammatory disease of the ear. |