| abstract |
The present disclosure relates to a lysine-AMP polypeptide construct, an isolated lysine polypeptide, and a pharmaceutical composition comprising the isolated polypeptide and/or a lysine-AMP polypeptide construct. Methods of using lysine-AMP polypeptide constructs, isolated lysine polypeptides and pharmaceutical compositions, including methods for treating bacterial infections or Gram-negative bacterial infections associated with biofilms of organs or tissues in the presence of pulmonary surfactants. Also provided herein. Also disclosed herein are lysine-AMP polypeptide constructs and isolated polynucleotides encoding isolated lysine polypeptides. |