| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d4ad61d0af1fd483d31d1c5df9b9b76 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate |
2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d688db06ef4212600cb6e45f5f08d9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fadb1730af68bd334416f316b9190d64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09fed5764c4c2dc2e5856ceafdbededf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b9429434b9da787215f1b974058ed4c |
| publicationDate |
2021-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20210048208-A |
| titleOfInvention |
Composition for preventing or treating TNF-mediated diseases comprising tetrahydropapaverine and method for inhibiting TNF-activity with the same |
| abstract |
The present invention relates to a composition for preventing or treating TNF-related diseases comprising tetrahydropaberine as an active ingredient and a method for inhibiting TNF activity using the same, wherein the tetrahydropaberine inhibits TNF activity, and in a collagen-induced arthritis model Protects bone and cartilage, reduces inflammatory cytokines, and inhibits the differentiation of Th17 cells and proliferation of fibroblast-like synovial cells.The tetrahydropaberine is a TNF-related disease including rheumatoid arthritis. It can be usefully used as a pharmaceutical composition for the prevention or treatment of, a health food composition for the prevention or improvement of TNF-related diseases, and the like. |
| priorityDate |
2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |