http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210043788-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b227bb4a6bb2e4a298835c360545fe9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f0f78695a58b2b942d0d101f14ee1a68 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-284 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-481 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-8905 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-8905 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-284 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-481 |
| filingDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d7ff56f877772749afd1f2c6a3ea323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09235275472f1e64267c6f0e5c8ac473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96370c1493e07d066061e6d47299e8d7 |
| publicationDate | 2021-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20210043788-A |
| titleOfInvention | Pharmacentical composition of JBD composition and method of analyzing ovarian function |
| abstract | The present invention relates to a composition and a method for analyzing female ovaries using the composition, comprising: an extraction step of extracting from hot water by adding distilled water to 7 kinds of herbal medicines; A separation step of centrifuging after heating the extract; A composition obtained by freeze-drying and powdering the supernatant obtained in the separation step; Analyzing the toxicity of the Jossui Bohyeoldan (JBD) composition by MTT; Measuring the weight, ovarian weight, and uterine weight of the mouse after administering the JBD composition to the mouse; Measuring the number of follicles after H & E staining on the mouse ovary and comparing the number of follicles before administration of JBD; Examining mRNA expression of molecules downstream of the mTOR/PI3K and Hippo signaling pathways in ovarian tissue; Examining mRNA expression of OCT4, a representative pluripotent stem cell marker, in ovarian tissue; Examining mRNA expression of angiogenesis and follicular development genes in ovarian tissue; Female ovary consisting of the steps of inducing superovulation after administering the JBD composition to NOA and POB mouse models, inducing superovulation, crossing with males, collecting and culturing fertilized eggs, and investigating the number and developmental capacity of the collected fertilized eggs. Provides a method for restoring ovarian aging by improving function, and according to the present invention, according to the mTOR / PI3K and Hippo signaling pathways in the aged ovary, ovarian stem cells are activated to produce high-quality oocytes to produce ovarian function and oocytes. It is a very useful invention that has the effect of improving the quality of cells and can provide a kit for analyzing female ovarian function using the same. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023153794-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102330544-B1 |
| priorityDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 397.