| abstract |
The present invention relates to a reverse aging induction method for returning aged cells to a young cell state by using a specific molecular target, and specifically, a composition for inducing reverse aging comprising a PDK1 (Phosphoinositide-dependent kinase-1) inhibitor or PDK1 It relates to a method for inducing reverse aging comprising the step of treating an inhibitor. PDK1 according to the present invention is a protein that simultaneously regulates MTOR and NF-кB among the major signaling proteins involved in cell aging, and is a key protein that determines the secretion phenotype related to cell growth, division, and aging. It was confirmed that some of the aged cells are effectively reversible to normal young cells, and the phenotype of the aged cells is no longer observed in these cells. Therefore, PDK1 presents a new possibility in the current aging treatment strategy, which is focused on the strategy of inducing the death of aged cells, and can be usefully used in the development of anti-aging substances and treatments for aging-related diseases. |