| abstract |
The present invention provides methods, pharmaceutical compositions and kits for treating cancer or an autoimmune disease in a patient in need thereof. These methods can be applied to patients in need of treatment with small ubiquitin-like modulators (Summary) activating enzyme (SAE) inhibitors, such as [(1R,2S,4R)-4-{[5-({4-[(1R)-7- Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxy-cyclopentyl] Methyl sulfamate (Compound I-263a) or a pharmaceutically acceptable salt in combination with one or more anti-CD20 antibodies. Medications for use in treating cancer or autoimmune diseases are also provided. |