| abstract |
Methods of synthesizing anhydrous sodium thiosulfate, anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity are described herein. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur and cetylpyridinium chloride. Anhydrous sodium thiosulfate is formulated as a pharmaceutical composition comprising a buffer and a solvent. Such compositions are useful for eliminating or reducing inner ear toxicity in pediatric patients receiving platinum-based chemotherapeutic agents. |