| abstract |
The present invention relates to the production of modified influenza virus proteins in plants. More specifically, the present invention relates to the production and increase of influenza virus-like particles (VLPs) in plants, the VLPs comprising modified influenza virus proteins, such as modified influenza hemagglutination (HA). The HA protein comprises an amino acid sequence comprising at least one substitution when compared to the corresponding wild-type amino acid sequence. A nucleic acid encoding the modified HA protein is further provided. In addition, methods of producing influenza virus like particles (VLPs) and methods of increasing the production yield of influenza virus like particles (VLPs) in plants, parts of plants, or plant cells are also provided. |