| abstract |
The present invention provides nucleic acids encoding acid α-glucosidase (GAA). In certain embodiments, the nucleic acid has greater than about 86% sequence identity to a sequence selected from the group consisting of any of the sequences set forth in SEQ ID NO: 1-5. In certain embodiments, the nucleic acid encoding acid α-glucosidase (GAA) contains less than 127 CpG dinucleotides. Expression cassettes, vectors, cells and cell lines, and methods of using such nucleic acids encoding acid α-glucosidase (GAA) are also provided. |