| abstract |
The present disclosure features a fusion protein that is a conditionally active variant of the cytokine of interest. In one aspect, the full-length polypeptide of the present invention has a reduced or minimal cytokine-receptor activation activity even when it contains a functional cytokine polypeptide. For example, upon activation of a blocking moiety, e.g., a steric blocking polypeptide, by cleavage of a linker that connects to a sequence for an active cytokine, the cytokine can bind to its receptor and affect signaling. have. |