| abstract |
The present invention relates to compositions and methods for transplantation of GABA neurons. GABA-related neurons according to the present invention and compositions comprising the same are used in cell-based therapy for the recovery or strengthening of central inhibition in the nervous system of a subject and for the treatment of neurological conditions, diseases and disorders associated with impaired or abnormal neurological function. Can be used. In a preferred embodiment, the transplant composition comprises a GABA neuron, a GFR-alpha agonist, and at least one cell death inhibitor, wherein the GABA neuron is produced by differentiating pluripotent stem cells, or multipotent stem or progenitor cells. |