| abstract |
Genome-edited chimeric antigen receptor T cells (CAR-T) are disclosed herein, which cells are from cytotoxic T cells, virus-specific cytotoxic T cells, memory T cells, or gamma delta (γδ) T cells. It may be derived and comprises one or more chimeric antigen receptors (CARs) targeting one or more antigens, wherein the CAR-T cell is at least one or more specifically bound to one or more CARs. There is a deficiency in the above antigens. In particular, the present specification relates to engineered mono, dual, and tandem chimeric antigen receptor (CAR)-carrying T cells (CAR-T) and immunotherapy methods for the treatment of such cancers. |