| abstract |
The present invention relates to chiral control oligonucleotides, chiral control oligonucleotide compositions, and methods of making and using the same. The present invention specifically aims to identify the source of certain problems associated with the prior art methodology for the production of chiral oligonucleotides, including problems that hinder the production of compositions that are specifically fully chirally controlled, particularly compositions comprising several oligonucleotide types. Include. In some embodiments, the present invention provides a chiral control oligonucleotide composition. In some embodiments, the invention provides chiral control oligonucleotides and methods of making chiral control oligonucleotide compositions. |