| abstract |
In one embodiment, the present invention provides a first monomer comprising a first variant Fc domain and a first heavy chain constant domain comprising a first antigen-binding domain, and a second heavy chain comprising a second variant Fc domain and a second antigen-binding domain A heterodimeric antibody comprising a second monomer comprising a constant domain is provided. In a further embodiment, the heterodimeric antibody comprises a first monomer comprising a first Fc domain and a heavy chain comprising a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. . The heterodimeric antibody further comprises a first heavy chain comprising a second Fc domain and a first variable heavy chain and a second monomer comprising a first light chain. |