| abstract |
The present invention is for the treatment or prevention of diseases associated with nerve fiber sensitization, and/or other pathological conditions associated with autonomic imbalance caused by increased chemoreceptor sensitivity, in particular respiratory disorders associated with increased activity of the P2X3 receptor, 1,3-thiazol-2-yl substituted as described and defined herein for the treatment of Chain Stokes respiration, central and obstructive sleep apnea, cardiovascular disease, hypertension, resistant hypertension, and heart failure. It relates to the use of benzamide compounds as well as pharmaceutical compositions and combinations comprising such compounds. |