| abstract |
The present invention can provide effective mechanical and biological support; In addition, when used as a bone graft, bioreactor or vector in the development, treatment and research of other biomaterials, extracellular bone matrix in gel form developed from decellularized animal bone tissue that can be reinforced with cell lines, nano compounds or drugs It relates to a biomaterial coated with; That is, decellularized, lyophilized, porous, robust bone material that is operable, safe and non-immunogenic, coated and reinforced with a substance that specifically stimulates bone tissue, provided/used as a particulate form or block. Therefore, when used as a bioreactor, it can promote the development of mature or progenitor cell lines in vitro, and when used as an in vivo graft, it is proven that it can fill bone defects and integrate and accelerate the process of cicarrization of fractures. Have the ability to become; This biomaterial is also based on the fact that the integrity of the extracellular organic matrix of bone tissue is maintained, promotes cell generation, improves scarring time, reduces cost, and decellularized organic matrix of biomaterials. Can contribute scientifically to basic research demonstrating engineering importance, research necessity and availability. |