| abstract |
Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for αvβ3 integrins and/or αvβ5 integrins and are conjugated to cargo molecules such as oligonucleotide-based therapeutic agents (e.g., RNAi agonists) to integrin αvβ3, integrin αvβ5, or integrin It is suitable for facilitating delivery of cargo molecules to cells and tissues expressing both αvβ3 and integrin αvβ5, such as tumor cells. Compositions and methods of use comprising an integrin targeting ligand are also described. |