| abstract |
The present invention is an antibody or fragment thereof comprising at least one heterologous amino acid sequence incorporated in at least one CDR region of the antibody or fragment thereof, wherein the at least one heterologous amino acid sequence is an N-terminal linker sequence (Ntls), atrial It relates to an antibody or fragment thereof comprising a natriuretic peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of the at least one CDR region is replaced by the at least one heterologous amino acid sequence incorporated therein. The invention further includes such antibodies or fragments thereof, compositions comprising such antibodies or fragments thereof, nucleic acids or mixtures of nucleic acids encoding such antibodies or fragments thereof, such nucleic acids or mixtures of such nucleic acids for use in therapeutic methods. Host cells and methods of producing such antibodies or fragments thereof. |