abstract |
The present invention relates to pyrazolo-pyridine compounds that inhibit mitogen-activated protein kinase kinase 4 (MKK4), in particular, which selectively inhibit MKK4 compared to protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. The compounds are also useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases. |