| abstract |
The present invention relates to a composition for preventing or treating atopy containing an extract of Jeolpaemo. When using the Jeolpaemo extract and its fractions of the present invention as an active ingredient, it has the effect of inhibiting the secretion of inflammatory cytokines interleukin-4 (IL-4), TARC, and MDC in vitro, and is a skin protective protein, filagrin. (filaggrin), Involucrin, aquaporin, transglutaminase (transglutaminase) has the effect of significantly increasing the expression. In addition, there is an effect of inhibiting the invasion of immune cells, CD4 cells and CD8 cells in the tissue in vivo, and significantly reducing skin thickness. Therefore, since it has an effect of preventing, treating or improving atopic dermatitis, it can be usefully used in various fields, such as pharmaceuticals, health functional foods, or cosmetics for preventing, treating or improving atopic dermatitis. |