abstract |
The present invention is a novel botulinum neurotoxin (BoNT) heavy chain binding domain (H C /) that is modulated to synergistically bind to synaptotagmin (Syt) receptor, synaptic associated vesicle 2 (SV2) receptor, and ganglioside (Gang) receptor. TAB) and a polypeptide comprising the novel H C /TAB, a vector encoding the polypeptide, and a use thereof. |