http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200123026-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0cefd36077e05d57ff9fca9250d762e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dd107091f6a3891b2cb5c21641981cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb5633dcce9c6d03a31957b8af2f2b0d |
| publicationDate | 2020-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20200123026-A |
| titleOfInvention | Multi-stimuli responsive block copolypeptide-based drug delivery systems |
| abstract | The present invention relates to a multi-stimulation responsive drug delivery system, specifically, a fusion polypeptide capable of forming and disintegrating nanostructures in response to temperature and pH stimulation, and a drug delivery system prepared using the same. The present invention prepares a fusion polypeptide in which a PEDF 34mer peptide capable of inhibiting angiogenesis, a hydrophilic elastin-based peptide, and a hydrophobic elastin-based peptide including Histidine are bonded to each other, and the fusion polypeptide has a core-shell structure under neutral conditions. It was confirmed that nanostructures could be produced, and the nanostructures collapsed under acidic conditions. Accordingly, the present invention can provide a multi-stimulation responsive drug delivery system capable of effectively delivering a drug by inhibiting angiogenesis and being introduced into a cell and decaying in an acidic condition. |
| priorityDate | 2019-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 410.