abstract |
The present invention provides an isolated or purified T cell receptor (TCR) having antigen specificity for MHC type II restricted MAGE-A3. The invention also provides related polypeptides and proteins, and related nucleic acids, recombinant expression vectors, host cells, and cell populations. Antibodies or antigen binding portions thereof and pharmaceutical compositions related to the TCR of the present invention are also provided by the present invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a mammal are also provided by the present invention. |