| abstract |
The present invention discloses a tetrahydropyrrole-based compound, its preparation method, pharmaceutical composition, and use. The tetrahydropyrrole compound of the present invention is as represented by the general formula (I). The tetrahydropyrrole-based compound of the present invention has a better inhibitory effect on the positive symptoms of schizophrenia, and its strength of action is equal to or slightly stronger than the positive drug olanzapine. In addition, the compounds of the present invention have a double inhibitory effect on D2 receptors and DAT receptors, can effectively treat schizophrenia, improve negative symptoms and cognitive function, and at the same time reduce vertebral side effects and prolactin secretion. |