| abstract |
Cyclin-dependent kinase (CDK) and a 2-aminopyrimidine-substituted 2H-indazole compound of the following formula (I) as a cell proliferation inhibitor, wherein R 1 is hydrogen, and a prodrug thereof, wherein R 1 is physiologically Group metabolizable under conditions), and their therapeutic uses and methods of preparation. These compounds, and pharmaceutically acceptable salts, solvates, prodrugs, and pharmaceutical compositions thereof, include, but are not limited to, a variety of cancer and inflammation-related diseases or conditions, including, but not limited to, cyclin-dependent kinases, especially CDK4/6 It is useful for treating diseases and disorders associated with the activity of |