| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e166ee6a4d4b4b799c315d2134715fc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2440-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e9ee8a70e30a0298984947ebff2a3f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6034ec5af5ed2f95940f5f91c9950a43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_807e0875a3a09bf56c59dfe38e6fae8e |
| publicationDate |
2020-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20200113721-A |
| titleOfInvention |
Method of screening nucleic acid based material targeting ITIH1 for treating disease related with hyperglycemia |
| abstract |
The present application discloses a method for screening a nucleic acid-based glycemic control substance targeting ITIH1. The method according to the present application is based on the discovery that an increase in OGT resulting from a decrease in G13 in a hyperglycemic state increases the stability of ITIH1, thereby increasing its expression level.ITIH1 binds to hyaluronic acid and deposits it in muscle and adipocytes, resulting in cellular insulin Reduces sensitivity. Therefore, a substance that targets ITIH1 and inhibits its expression can be effectively used as a therapeutic agent for a disease requiring blood sugar control. |
| priorityDate |
2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |