| abstract |
Substituted furanopyrimidine chemical entities of formula (I): , Wherein R a is any value described herein, and a composition comprising such a chemical entity; Its manufacturing method; And use in a wide range of methods, including metabolic and reaction kinetics studies; Detection and imaging technology; Radiotherapy; Modulation and treatment of disorders mediated by PDE1 activity or dopaminergic signaling; Treatment of nervous system disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma dependent loss of function; Stroke treatment, including cognitive and motor deficits during stroke rehabilitation; Nerve protection and promotion of nerve recovery; Improving the effectiveness of cognitive and motor training, including animal skill training protocols; And the treatment of peripheral disorders, including cardiovascular, kidney, hematology, gastroenterology, liver, cancer, reproductive, and metabolic disorders. |