| abstract |
An immunoconjugate having the formula Ab-[L 1 -(AL 2 -B) m ] n , wherein: (a) Ab is an antibody or binding fragment thereof; (b) L 1 and L 2 are each independently a linker, L 1 and L 2 may be the same or different, and L 1 is bonded to L 2 ; (c) A is a target-protein ligand/binding agent; (d) B is a ubiquitin ligation enzyme ligand/binding agent, and (e) n and m are each independently an integer of 1 to 8. Target proteins include kinases, G protein-bound receptors, transcription factors, phosphatase, and RAS superfamily members. |