| abstract |
The present invention is a basal insulin having a pH of 6.0 to 8.0 and an isoelectric point (pI) of 5.8 to 8.5; b) and a composition in the form of an aqueous solution for injection comprising a co-polyamino acid consisting of glutamic acid or aspartic acid units as defined in the claims. In one embodiment, the composition according to the invention is characterized in that the co-polyamino acid carrying a carboxylate charge and at least one hydrophobic radical Hy is selected from co-polyamino acids according to formula XXXb: wherein D is Independently represents a CH 2 group (aspartic acid) or a CH 2 -CH 2 group (glutamic acid); X represents a cationic entity selected from the group containing alkali cations; R b and R b ′ are the same or different, and a hydrophobic radical -Hy, or H, a linear acyl C2 to C10 group, a branched acyl C3 to C10 group, benzyl, a terminal "amino acid" unit and a group consisting of pyroglutamate Is a radical selected from; At least one of Rb and R'b is a hydrophobic radical Hy; Q and Hy are as defined above; n + m is DP, which is the degree of polymerization of the co-polyamino acid, that is, the average number of monomer units per co-polyamino acid chain, and is 5≦n+m≦250. |