| abstract |
The present invention relates to imide-based compounds as well as bifunctional compounds comprising them, which are modulators of targeted ubiquitination, in particular degraded and/or otherwise inhibited by the bifunctional compounds according to the invention. Finds usefulness as inhibitors of various polypeptides and other proteins. In particular, the present invention binds a ligand that binds to Cerebloon E3 ubiquitin ligase at one end and a target protein at the other end so that the target protein is placed in close proximity to the ubiquitin ligase to achieve degradation (and inhibition) of the protein. It provides a compound containing a moiety. Compounds can be synthesized that exhibit a wide range of pharmacological activities consistent with degradation/inhibition of virtually any type of targeted polypeptide. |